What they do and Why We Need Them What Are Systemic Enzymes and What Do They Do By Dr. William Wong ND, Ph. DThe word systemic means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ. Activation Proteolytic Enzymes' title='Activation Proteolytic Enzymes' />Enzymes are biological catalysts responsible for supporting almost all of the chemical reactions that maintain animal homeostasis. Because of their role in. Vitalzym XE 180 caps by World Nutrition PLEASE NOTE If you would like to find out the price on this product, please create a login or call us at 18667574500 x 702. ENZYMES LOSSES ARE DEADLY. People are eating cooked foods which totally destroy all life giving enzymes. This basically removes the gasoline out of their car and. Plasmin is a serine protease that acts to dissolve fibrin blood clots. Apart from fibrinolysis, plasmin proteolyses proteins in various other systems It activates. Fig_3.png' alt='Activation Proteolytic Enzymes' title='Activation Proteolytic Enzymes' />CHAPTER 7 Formation of Disulfide Bonds in Synthetic Peptides and Proteins David Andreu, Fernando Albericio, lVtiria A. Sol, Mark C. Munson. The Wider Benefits of Multi Enzyme Therapy. Enzymes are synergistic in nature enzymes do not exist singly, rather many occur together in foods, the presence of one. What are Vitalzym Systemic Enzymes Vitalzym is one of the most powerful and fast working systemic proteolytic enzymes on the market. Enzymes are needed for each of. Enzymes are incredibly efficient and highly specific biological catalysts. In fact, the human body would not exist without enzymes because the. Digestive enzymes are enzymes in the alimentary tract with a purpose of breaking down components of food so that they can be taken up by the organism. Activation Proteolytic Enzymes' title='Activation Proteolytic Enzymes' />But lets take first things first, what is an enzyme An enzyme is a biocatalyst something that makes something else work or work faster. Chemical reactions are generally slow things, enzymes speed them up. Without enzymes the chemical reactions that make up our life would be too slow for life as we know it. As slow as sap running down a tree in winter. For life to manifest as we know it, enzymes are essential to speed up the reactions. We have roughly some 3. Most of these enzymes are derived or created from what we think of as the protein digesting enzymes. But while digestion is an important part of what enzymes do, its almost the absolute last function. First and foremost these body wide proteolytic protein eating enzymes have the following actions Natural Anti Inflammatory. They are the first line of defense against inflammation. Inflammation is a reaction by the immune system to an irritation. Lets say you have an injured right knee. The immune system sensing the irritation the knee is undergoing creates a protein chain called a Circulating Immune Complex CIC for short, tagged specifically for that right knee. The Nobel Prize in biology was won in 1. This CIC floats down to the right knee and causes pain, redness and swelling are the classic earmarks for inflammation. This at first is a beneficial reaction it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self perpetuating, itself creating an irritation that the body makes CICs to in response Aspirin, Ibuprofen, Celebrex, Vioxx and the rest of the Non Steroidal Anti Inflammatory Drugs all work by keeping the body from making all CICs. This ignores the fact that some CICs are vital to life, like those that maintain the lining of the intestine and those that keep the kidneys functioningNot to mention the fact that the NSAIDs, along with acetaminophen, are highly toxic to the liver. Every year 2. 0,0. Americans die from these over the counter drugs and another 1. Systemic enzymes on the other hand are perfectly safe and free of dangerous side effects. They have no LD 5. Best of all systemic enzymes can tell the difference between the good CICs and the bad ones because hydrolytic enzymes are lock and key mechanisms and their teeth will only fit over the bad CICs. So instead of preventing the creation of all CICs, systemic enzymes just eat the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also. Anti Fibrosis. Enzymes eat scar tissue and fibrosis. Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain. As we age, which starts at 2. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 2. At that point the body knows that if it keeps up that rate of consumption well run out of enzymes and be dead by the time we reach our 4. Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually dont make it past their 2. So our body in its wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon as a result the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic meaning scar tissue plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars. If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be eaten away from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 4. Blood Cleansing. The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its first pass, or the first time it goes through but given the sluggish and near toxic or toxic states of everyones liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. Breaking dead material down small enough that it can immediately pass into the bowel. Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. And here we come to the only warning we have to give concerning the use of systemic enzymes dont use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin, Heparin and Plavix, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much. Immune System Modulating. Enzymes are adaptogenic seeking to restore a steady state to the body. When the immune system is running low we become susceptible to infectious disease, when its cranked up too high then the system creates antibodies that attack its own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue. Virus Fighting. Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, again the enzyme lock and key mechanism. One note many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf MD Ph. D x. Columbia University in the 4. There are currently over 2. A search through Pub Med using the key words serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Enzymes, Kinetics and Diagnostic Use 1. LLC info. themedicalbiochemistrypage. Introduction to Enzymes. Enzymes are biological catalysts responsible for supporting almost all of the. Because of their role in. The. macromolecular components of almost all enzymes are composed of protein, except. RNA catalysts known as. The. term ribozyme is derived from ribonucleic acid enzyme. Most of the characterized ribozymes are molecules of ribonucleic acid that catalyze reactions on one of their own phosphodiester bonds or within other RNAs. In addition, there are known ribozymes that. Enzymes are found in all tissues and fluids of the. Intracellular enzymes catalyze the reactions of metabolic pathways. Plasma membrane enzymes regulate catalysis within cells in response to. Almost every significant life process is dependent on enzyme activity. Enzyme Classifications. Traditionally, enzymes were simply assigned names by. As knowledge expanded, systems of. Currently enzymes. International Union of. Biochemists I. U. B. Number. Classification. Biochemical Properties. Oxidoreductases. Act on many chemical. How To Write Program In J2me. Transferases. Transfer functional groups. Kinases are specialized transferases. ATP to other. Add water across a bond. Add water, ammonia or. Carry out many kinds of isomerization. L to D isomerizations, mutase reactions shifts of chemical groups and. Catalyze reactions in. ATP. These rules give each enzyme a unique number. The. I. U. B. system also specifies a textual name for each enzyme. The enzymes name. Because many enzymes, such as alcohol dehydrogenase, are. I. U. B. approved nomenclature has been slow. In everyday usage, most enzymes are. Enzymes are also classified on the basis of their. Enzymes composed wholly of protein are known as simple. Complex enzymes are also. In this terminology the protein component is known. Many prosthetic groups. It should be noted that the main clinical symptoms of dietary vitamin insufficiency generally arise from the. The non protein component of an. Enzymes that require a metal in their composition are known. Those which have a lower affinity for metal ion, but still require the metal. Role of Coenzymes. The functional role of coenzymes is to act as transporters. The chemical groups carried. H 2e. carried by NAD or the mole of hydrogen carried by FAD or they can be even more. NH2 carried by pyridoxal phosphate. Since coenzymes are chemically changed as a. In. all cases, the coenzymes donate the carried chemical grouping to an acceptor. This regeneration of. Enzyme Relative to Substrate Type. Although enzymes are highly specific for the kind of. For example, while succinate dehydrogenase SDH always catalyzes an. ADH always catalyzes oxidation reduction reactions but. Generally, enzymes having broad substrate specificity are most active against. In the case of ADH, ethanol is the preferred. Enzymes also are generally specific for a particular. Enzymes that attack D. L isomer. Enzymes that act on L amino. D optical isomer as a substrate. The. enzymes known as racemases provide a striking exception to these generalities. D isomers to L isomers and vice. Thus, racemases attack both D and L forms of their substrate. As enzymes have a more or less broad range of. The individual members of a set of enzymes. These are the products of genes that vary only slightly often, various. The best. studied set of isozymes is the lactate dehydrogenase LDH system. LDH is a. tetrameric enzyme composed of all possible arrangements of two different. H for heart and M for skeletal. These subunits combine in various combinations leading to 5 distinct. The all H isozyme is characteristic of that from heart tissue, and. M isozyme is typically found in skeletal muscle and liver. These. isozymes all catalyze the same chemical reaction, but they exhibit differing. The detection of specific LDH isozymes in the blood is. Enzyme Substrate Interactions. The favored model of enzyme substrate interaction is. This model. proposes that the initial interaction between enzyme and substrate is. After binding takes place, one or more. The possible mechanisms of catalysis are four in number 1. Catalysis by Bond Strain In this. The new conformation. Catalysis by Proximity and Orientation. Enzyme substrate interactions orient reactive groups and bring them. In addition to inducing strain, groups such as. Catalysis Involving Proton Donors Acids and. Acceptors Bases Other mechanisms also contribute significantly to. Covalent Catalysis In catalysis. One of the best known examples of. These proteases. contain an active site serine whose R group hydroxyl forms a covalent bond with. Chemical Reactions and Rates. According to the conventions of biochemistry, the. Reaction. rate is always dependent on the concentration of the chemicals involved in the. For. example, the reaction in which A is converted to B is written as follows A  BThe rate of this reaction is expressed algebraically. A A kBor an increase in the concentration of product B B kAIn the second equation of the 3 above the negative. A as the reaction progresses. Rate constants are simply proportionality constants that provide a. Each chemical reaction has characteristic values for its rate constants these. Thus, reaction can be rewritten. The. rate constant for the forward reaction is defined as k1 and the. At equilibrium the rate v of the forward reaction A  B is, by definition, equal to that of the reverse or back. B  A, a relationship which is algebraically symbolized as vforward vreversewhere, for the forward reaction vforward k1Aand for the reverse reaction vreverse k1BIn the above equations, k1 and k1. The negative subscript refers only to a reverse reaction, not to an actual. Reflector 2. To put the relationships of the two equations. A. The rate of the reverse reaction is equal to the. B. At equilibrium, the rate of the forward reaction is. This. equation demonstrates that the equilibrium constant for a chemical reaction is. Examples of Coupled Reactions in Biology. Lets look at the hypothetical reaction A  B. If this is a. thermodynamically unfavorable reaction the Go value will be positive. Lets assume it is 4. In order to drive this reaction in the direction written it can be coupled to the hydrolysis of ATP. The free energy. of ATP hydrolysis to ADP is shown ATP H2. O  ADP Pi Go 7. Coupling the two reactions together gives the equation A ATP H2. O  B ADP Pi HThe Go for this coupled reaction is the sum of the Go values of the two separate. This indicates that coupling ATP hydrolysis. A to B thermodynamically favorable. Another useful example is to examine one of the reactions of. In this case we will look at. PK. phosphoenolpyruvate  pyruvate Go 1. This reaction releases sufficient energy to drive. ATP from ADP which would normally be thermodynamically. Go of 7. 3kcalmol. Note that this value is the reciprocal. ATP. This points out another fact that the Go for a reaction. Coupling the two. ADP H  pyruvate ATP Go 7. The overall Go value is, as indicated, simply the arithmetic sum of the Go. Chemical Reaction Order. Reaction order refers to the number of molecules. Empirically, order is easily determined by summing the exponents of. A reaction. characterized by the conversion of one molecule of A to one molecule of B with. The exponent on the substrate. A reaction. with two substrates forming two products would a second order reaction. However, the reactants in second and.